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ACTIV-3 THERAPEUTICS FOR INPATIENTS WITH COVID-19 (TICO)

This study tests the use of standard treatments plus an investigational therapeutic to help people who are in the hospital with COVID-19 recover in a shorter time.

WHAT IS THE STUDY ABOUT?

The ACTIV-3 Therapeutics for Inpatients with COVID-19 (TICO) study is trying to find new treatments for people in the hospital with COVID-19. Researchers want to see if the study drugs are safe and help people with COVID-19 get better faster and stay better compared with people who do not get the study drug. The study drugs kill the virus that causes COVID-19 or stop it from multiplying. We hope this will lower the amount of virus in the body and help people with COVID-19 get better faster.

Study participants will receive either a study drug along with standard treatment for COVID-19, or a placebo (salt water that has no effect). All participants will also receive standard treatment for COVID-19. Different study drugs are being tested, which gives participants a greater chance of getting a study drug. The odds of receiving a study drug will depend completely on chance and will always be at least 50% (50:50). Doctors are hoping to answer important research questions, including:

  • Do these study drugs help people in the hospital recover more quickly from COVID-19, letting them to go home faster and stay out of the hospital?
  • Will these study drugs reduce the need for oxygen therapy or breathing support?
  • Will these study drugs lower the risk of serious illness or death?
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You will be asked to take part in this study for 18 months. You will be checked to make sure you qualify for the study. Most of your study checks or visits will be in the first 90 days and the rest at 6, 12, and 18 months. While you are in the hospital, the study team will check on your health frequently. There will be nine study checks during the first month—at least four of these checks will be in-person visits. Over the rest of the study, there will be seven more study checks. Only one will be in person (the other six can take place by phone). At some visits, blood and nose swab samples will be taken.


WHO CAN JOIN THIS STUDY?

If you recently tested positive and are in the hospital with COVID-19, this study may be for you. Clinical trials testing COVID-19 treatments need people from diverse backgrounds. This will help researchers find treatments that are safe and work for more people. Each person who takes part in the TICO study will meet specific conditions, including:

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Age

At least 18 years old

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COVID-19 Status

Currently in the hospital due to COVID-19

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Symptoms

Have COVID-19 symptoms for up to 12 days

HOW CAN I JOIN THIS STUDY?

If you are interested in joining the ACTIV-3 TICO clinical trial or you would like more information:

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RESOURCES

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ACTIV-3 TICO POWERPOINT PRESENTATION

ACTIV-3 TICO TRIAL LOCATIONS

Find an ACTIV-3 TICO trial site near you:

Show locations


ANSWERS TO OTHER QUESTIONS YOU MIGHT HAVE

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A clinical research study helps doctors find new treatments that are safe and effective. It is important that these studies include people from diverse backgrounds. This helps researchers develop new treatments that will work for more people.

The placebo looks like the study medication but does not have any active ingredients in it. Researchers compare how people react to both placebos and medications to learn if the medication is safe and helps people recovery more quickly. If you join this study, you will get the usual care for COVID-19.

Yes. Taking part in this clinical trial is voluntary; it is your choice. You can change your mind at any time and leave the study.