This page is no longer being updated. For the latest updates on COVID-19, including vaccines and treatments, please visit www.cdc.gov/coronavirus. Healthcare professionals, please visit aspr.hhs.gov/COVID-19/Pages/default.aspx and www.covid19treatmentguidelines.nih.gov.
ACTIV-6: A CLINICAL RESEARCH STUDY
ACTIV-6 is a virtual study for people with mild-to-moderate COVID-19 symptoms. This is a time sensitive study that you can participate in from the comfort of your home!

WHAT IS THIS STUDY ABOUT?
ACTIV-6 is a large clinical research study testing existing medications for use on adults with mild-to-moderate COVID-19 symptoms who are not sick enough to be hospitalized. The ACTIV-6 study aims to answer questions such as:
- Can we find medications that can be easily given at home to treat people with COVID-19?
- Will these medications prevent the disease from getting worse?
You can participate from anywhere in the United States. The medications are shipped to your home at no cost. If you participate in the study, you will receive a medication or a placebo that looks like the medication but has no actual medicine in it. You will be asked how you feel in a series of online or phone surveys for 14 to 28 days. After 90 days you will complete a follow-up survey.
ACTIV-6 is focusing on medications that have already been approved by the U.S. Food & Drug Administration for use in other conditions. Visit the ACTIV-6 website to learn more about the medications being tested. Results from ACTIV-6 will help researchers understand how existing medications can improve symptoms and limit hospitalizations for people with mild-to-moderate COVID-19.
WHO CAN JOIN THIS STUDY?
If you recently tested positive for COVID-19, this study may be for you. Clinical trials testing COVID-19 treatments need people from diverse backgrounds. This will help researchers find treatments that are safe and work for more people. Each person who takes part in the ACTIV-6 study will meet specific conditions, including:

At least 30 years old

Not in the hospital, tested positive for COVID-19

At least two COVID-19 symptoms for no longer than 7 days
HOW CAN I JOIN THIS STUDY?
Joining the ACTIV-6 study needs to happen soon after the start of your COVID-19 symptoms. You can learn more and join by:

Participating in ACTIV-6 is possible from your home as the medications will be mailed to you. In addition, you may find an in-person ACTIV- 6 study site near you.

ANSWERS TO OTHER QUESTIONS YOU MIGHT HAVE

A clinical research study helps experts find treatments that are safe and effective. It is important that these studies include people from diverse backgrounds. This helps researchers develop new treatments that will work for more people.
The placebo looks like the study medication but does not have any active ingredients in it. Researchers compare how people react to both placebos and medications to learn if the medication is safe and helps people recovery more quickly. If you join this study, you will get the usual care for COVID-19.
Yes. Taking part in this clinical trial is voluntary; it is your choice. You can change your mind at any time and leave the study.